Eukaryote-Specific Insertion Elements Control Human ARGONAUTE Slicer Activity
نویسندگان
چکیده
منابع مشابه
Human Argonaute3 has slicer activity
Of the four human Argonaute (AGO) paralogs, only AGO2 has been shown to have slicer activity. The others (AGO1, AGO3 and AGO4) have been thought to assemble with microRNAs to form slicer-independent effector complexes that bind target mRNAs and silence gene expression through translational repression and deadenylation but not cleavage. Here, we report that recombinant AGO3 loaded with miR-20a c...
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ژورنال
عنوان ژورنال: Cell Reports
سال: 2013
ISSN: 2211-1247
DOI: 10.1016/j.celrep.2013.06.010